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患有慢性乙型肝炎病毒感染的患者非常低水平病毒病的危险因素:单中心回顾性研究

Jiahui Lu¹, Congnan Zhang¹, Pengyuan He¹

¹Department of Infectious Disease, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.

|February 17, 2025

概括

乙型肝炎抗原 (HBeAg) 血清阳性和高乙型肝炎表面抗原 (HBsAg) 水平是慢性乙型肝炎 (CHB) 抗病毒治疗期间非常低水平病毒病 (VLLV) 的关键危险因素. 监测这些标记可以帮助预测和管理VLLV.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
传染性疾病传染性疾病

背景情况:

针对乙型肝炎病毒 (HBV) 的抗病毒疗法可能导致肝脏并发症.
低水平病毒病 (LLV),定义为HBV DNA<2000 IU/mL,是这些并发症的一个重要因素.
非常低水平的病毒性血清 (VLLV),HBV DNA 9-20 IU/mL,需要特定的风险因素识别.

研究的目的:

在接受慢性乙型肝炎 (CHB) 抗病毒治疗的患者中,研究与非常低水平病毒病 (VLLV) 相关的危险因素.

主要方法:

对139名患有VLLV的CHB患者和139名与持续病毒学反应相匹配的对照进行了回顾性分析.
从2016年10月到2021年4月收集的数据,包括核酸类比处理.
多变量分析以确定VLLV的独立风险因素.

主要成果:

乙型肝炎抗原 (HBeAg) 血清阳性 (aOR 3.63) 和较高的乙型肝炎表面抗原 (HBsAg) 水平 (aOR 2.21) 是VLLV.的独立风险因素.
在HBeAg阳性患者中,男性性别和高HBsAg水平是显著的预测因素.
无论是HBsAg还是HBeAg,都显示出对VLLV的预测价值.

结论:

在接受抗病毒治疗的CHB患者中,HBeAg血清阳性和升高的HBsAg水平是VLLV的显著风险因素和预测因素.
在治疗48周后,持久的HBeAg阳性和高HBsAg水平的患者需要密切监测VLLV.
建议使用高度敏感的HBV DNA检测方法来管理VLLV风险.

关键词:

慢性乙型肝炎 (CHB) 是一种乙型肝炎病毒 (HBV)风险因素风险因素非常低水平的病毒性血清 (VLLV)

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