美国成年人因任何原因死亡的风险 保持比率 损伤的螺旋计:一项观察性研究
Shan Xiao1, Jie Ou2, Wangli Qiu3
1Department of Pulmonary and Critical Care Medicine, Shenzhen Longgang District Central Hospital, Shenzhen, People's Republic of China.
International journal of chronic obstructive pulmonary disease
|February 17, 2025
概括
保存比率受损螺旋计 (PRISm) 在一般人群中显著增加了所有原因的死亡风险. 这项研究强调了PRISm作为长期健康结果的关键指标.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 保存比值受损螺旋计 (PRISm) 是通过特定的螺旋计值 (预测FEV1/FVC ≥ 0.70和FEV1 < 80%) 定义的.
- 以前的研究表明,PRISM可能导致气流阻塞和死亡风险升高.
- 关于PRISm的长期随访数据和一般人群研究有限.
研究的目的:
- 调查PRISm与所有原因死亡风险之间的关联.
- 评估这一关联在一般人口的大型代表性样本中.
- 提供关于PRISm和死亡率的长期随访数据.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) III和2007-2012年的数据.
- 包括年龄在20-79岁之间的参与者,具有螺旋计数据.
- 使用Cox比例危险回归模型进行死亡风险分析,并进行灵敏度和子组分析.
主要成果:
- 分析了24,691名参与者的数据,平均随访时间为25.7年.
- PRISm (1452名参与者) 与所有原因死亡率的增加显著相关 (调整后HR=1.69).
- 敏感性和子组分析证实了PRISm个体的高死亡风险.
结论:
- 与正常螺旋计相比,PRISm与一般人群中所有原因死亡的风险更高有显著联系.
- 这些发现强调了PRISm的临床意义.
- 需要进一步的研究来探索PRISm的潜在干预措施.
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