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相关概念视频

Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
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Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
374
Bile01:19

Bile

457
Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
457
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

70.4K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
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Lipid Absorption01:24

Lipid Absorption

345
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
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Lipid Digestion01:06

Lipid Digestion

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Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
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相关实验视频

Updated: May 27, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

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在发育中的儿童中,胆酸和微生物群的相互作用

Mary Elizabeth M Tessier1, Benjamin L Shneider1, Joseph F Petrosino2

  • 1Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, USA.

Journal of pediatric gastroenterology and nutrition
|February 17, 2025
PubMed
概括

婴儿的肠道微生物群和胆酸池随着时间的推移而成熟,影响儿科肝病. 了解这些相互作用对于开发用于胆固醇性肝病的新疗法至关重要.

关键词:
胆道缩症 胆道缩症胆固醇的发生.进入肝脏循环中的肝脏循环.婴儿 婴儿 婴儿 婴儿

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Bile Salt-induced Biofilm Formation in Enteric Pathogens: Techniques for Identification and Quantification
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Bile Salt-induced Biofilm Formation in Enteric Pathogens: Techniques for Identification and Quantification

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Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
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Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

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相关实验视频

Last Updated: May 27, 2025

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Bile Salt-induced Biofilm Formation in Enteric Pathogens: Techniques for Identification and Quantification
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Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
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科学领域:

  • 胃肠病学和肝病学 胃肠学和肝病学
  • 微生物学 微生物学
  • 儿科医学 儿科医学

背景情况:

  • 胆酸代谢和肠道微生物组成在婴儿和成年人之间存在显著差异.
  • 婴儿的肠道微生物组从一个简单的,Bifidobacterium占主导地位的社区演变为一个多样化的,类似成人的状态.
  • 这种微生物继承通过微生物活动,如脱和氧化,影响胆酸池的成熟.

研究的目的:

  • 审查儿科与成人肠道微生物组和胆酸池的差异.
  • 讨论在生命早期肠道微生物和胆汁酸之间的关键相互作用.
  • 探索这些相互作用如何影响婴儿和患有胆固醇性肝病的儿童的结果,例如胆道缩.

主要方法:

  • 文献综述侧重于儿科和成人肠道微生物组和胆酸研究.
  • 在生命早期对微生物继承和胆酸池成熟的比较分析.
  • 在儿科肝病中探索微生物组和胆酸之间的双向关系.

主要成果:

  • 婴儿肠道微生物最初很简单,胆酸池主要由初级胆酸主导.
  • 微生物继承导致微生物多样性的增加和二次胆汁酸的产生.
  • 改变胆汁酸概况可以影响微生物组的发展,反之亦然,影响肝脏健康.

结论:

  • 肠道微生物群和胆汁酸之间的动态相互作用对于儿童的正常发育和健康至关重要.
  • 这种相互作用的失调与儿科胆固醇性肝病有关.
  • 进一步了解这些机制可以为儿童肝脏疾病的新疗法策略提供信息.