EndoFLIP 延展性指数与患有埃索因性食道炎的儿童的组织学发现相关
Erik Almazan1, Tom Z Liang2, Brenna Hohl3
1Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Journal of pediatric gastroenterology and nutrition
|February 17, 2025
概括
内膜功能性光膜成像探针 (EndoFLIP) 的测量与儿科异性食道炎 (EoE) 的组织学得分相关,这表明它可以帮助评估食道重塑.
科学领域:
- 胃肠病学 胃肠病学
- 儿科胃肠病学 儿科胃肠病学
- 食道疾病 食道疾病
背景情况:
- 乙性食道炎 (EoE) 诊断依赖于乙性食道炎史学评分系统 (EoEHSS).
- 在EoEHSS中评估自身膜纤维化是具有挑战性的.
- 来自EndoFLIP的低张力度指数 (DI) 与儿科EOE中的纤维肌痛严重程度相关.
研究的目的:
- 调查通过EndoFLIP和EoEHSS得分测量的DI之间的相关性.
- 确定EndoFLIP是否可以补充EoEHSS来评估患有EoE的儿童的食道重塑.
主要方法:
- 对21岁以下经过EGD与活检和EndoFLIP的患者的回顾性审查.
- 在正常/反应性,反流和EoE组之间比较EoEHSS得分和光参数.
- 对30毫升通胀时DI的分析与EoEHSS得分相比.
主要成果:
- 30毫升的日均通货膨胀率在EoE组中最低 (p=0.03).
- DI与整体EoEHSS等级有负相关性,并且对乙氨基酸,表面分层,扩张的细胞间空间和基底区域增生 (所有p<0.05) 的得分.
- 此外,DI与乙酸性炎症阶段评分 (p<0.05) 有负相关性.
结论:
- 用EndoFLIP测量30mL通胀时的DI与EoEHSS得分和子得分有负相关性.
- 在儿童中,EndoFLIP显示出作为评估EoE相关食道重塑的补充工具的潜力.
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