在子宫内膜异位症患者中,细肠细菌过度生长和肠道甲素过度生长的高患病率:一个病例对照研究
Philippe Halfon1,2, Jean-Philippe Estrade3, Guillaume Penaranda2
1Hôpital Européen, Marseille, France.
概括
一项研究发现,在患有子宫内膜异位症的妇女中,小肠细菌过度生长 (SIBO) 和肠子甲素过度生长 (IMO) 的比率显著更高. 评估消化系统过度生长可能为子宫内膜异位症患者提供新的治疗策略.
科学领域:
- 胃肠病学 胃肠病学
- 妇科 妇科医生 妇科
- 微生物学 微生物学
背景情况:
- 子宫内膜异位症是一种慢性炎症状况,影响生育年龄的女性.
- 胃肠道症状在子宫内膜异位症患者中很常见,但其潜在原因尚未完全理解.
- 小肠细菌过度生长 (SIBO) 和肠道甲素过度生长 (IMO) 是这些症状的潜在贡献者.
研究的目的:
- 调查被诊断患有子宫内膜异位症的妇女中SIBO和IMO的患病率.
- 为了比较子宫内膜异位症患者和对照组之间SIBO和IMO的患病率.
- 突出评估SIBO/IMO在子宫内膜异位症管理中的重要性.
主要方法:
- 一项涉及1027名女性的病例控制研究,在2021年11月至2023年6月期间接受乳糖呼吸测试 (LBT).
- 通过MRI或组织学确认的148名子宫内膜异位症患者与同等数量的对照进行了匹配.
- 使用LBT来诊断SIBO和/或IMO.
主要成果:
- 与对照组 (83.1%) 相比,子宫内膜异位症患者 (91.9%) 的SIBO/IMO患病率明显高,P=0.0223.3.
- 子宫内膜异位症患者表现出改变过渡 (85.8%vs71%),便秘 (67.8%vs44.7%) 和头 (44.8%vs28.7%) 的增加.
- 在63.2%的阳性子宫内膜异位症病例中,甲过度生长是普遍存在的. SIBO H2与腹风险相关,IMO与酸性反流风险相关.
结论:
- 异常的消化系统过度生长,包括SIBO和IMO,在子宫内膜异位症患者中非常普遍.
- 在所有子宫内膜异位症病例中,应考虑对SIBO/IMO进行评估.
- 识别和治疗SIBO/IMO可能是治疗子宫内膜异位症的新途径.
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