微生物组作为神经健康的调节器,跨越了母婴接口
Stephanie B Orchanian1, Elaine Y Hsiao1,2
1Department of Integrative Biology and Physiology, UCLA, Los Angeles, California, USA.
The Journal of clinical investigation
|February 17, 2025
概括
孕产妇的微生物组显著影响孕产妇和后代的神经健康. 了解这些肠道微生物的影响可能会导致新的健康干预措施.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 孕产妇的微生物组在孕产妇和后代的神经健康中起着至关重要的作用.
- 肠道微生物群落影响生命早期发展和长期健康轨迹.
- 微生物组-肠-大脑轴正在扩展,包括围产期的母子信号.
研究的目的:
- 审查有关母亲微生物组如何调节母亲和后代的大脑功能和行为的文献.
- 探索神经发育异常中母亲微生物组与环境因素之间的相互作用.
- 讨论用于神经调节的母子交叉通话机制.
主要方法:
- 现有人类和动物研究的综合.
- 对母亲微生物组对神经发育的影响的证据分析.
- 对参与母婴信号传递的分子和细胞机制的审查.
主要成果:
- 孕产妇的微生物组影响母亲和发育中的后代的脑功能和行为.
- 母体微生物群落与环境因素相互作用,影响神经发育风险.
- 证据支持微生物组介导的神经调节的特定分子和细胞途径.
结论:
- 孕产妇的微生物组是孕产妇和后代神经健康的关键因素.
- 了解母婴微生物组相互作用可以为神经发育健康提供信息.
- 未来的研究可能会导致基于微生物组的策略,以促进母亲和儿童的福祉.
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