在牛皮,抑郁症和焦虑症中,有助于炎症的细胞因子和神经
Emily L Keenan1, Richard D Granstein1
1Israel Englander Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.
Acta physiologica (Oxford, England)
|February 17, 2025
概括
牛皮与抑郁症和焦虑症等心理健康问题有关. 抗炎性细胞因子和神经可以连接炎症,压力和牛皮,强调综合心理健康护理的必要性.
科学领域:
- 皮肤病学 皮肤病学
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 牛皮常常伴随着精神疾病,包括抑郁症和焦虑症.
- 系统性炎症是牛皮的标志,心理压力是常见的触发因素和加重因素.
- 免疫,神经和内分泌系统之间的相互作用在慢性炎症疾病中越来越被认可.
研究的目的:
- 审查有关促炎性细胞因子和神经在连接系统性炎症,心理压力和牛皮中的作用的当前理论和证据.
- 分析连接牛皮,精神病并发症和压力的生物媒介.
- 突出管理压力和精神健康在牛皮患者的重要性.
主要方法:
- 进行了全面的文献审查.
- 分析了检查牛皮,精神疾病和生物媒介之间的联系的研究.
- 研究的关键介质包括炎症性细胞因子 (例如TNF-α,IL-17,IL-22) 和神经 (例如CGRP,SP,VIP),以及HPA轴.
主要成果:
- 精神状态通过免疫,神经和内分泌通路影响皮肤状况.
- 牛皮患者的高焦虑和抑郁症归因于炎症和与疾病相关的压力.
- 预炎性细胞因子和神经被认为是系统性炎症,牛皮和精神病并发症之间的关键联系.
结论:
- 管理压力和解决心理健康问题对于改善牛皮的临床结果至关重要.
- 需要进一步的研究,以充分阐明所涉及的生理机制.
- 了解这些联系可能会为针对皮肤和心理健康的新型治疗策略铺平道路.
相关概念视频
01:24T Cell Types and Functions
897
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
897
01:30Stress and Mental Health
71
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
71
01:27Psychoneuroimmunology: Cardiovascular Disease
25
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
25
01:31Neurotransmitters
774
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
774
01:19Psychoneuroimmunology: Diabetes and Cancer
21
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
21
01:28Inflammatory Response
1.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.8K