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白质损伤介于大脑年龄对大脑小血管疾病的认知功能的影响

Yuanhao Li¹, Tian Tian¹, Yuanyuan Qin¹

¹Department of Radiology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Jiefang Road 1095, Wuhan, China.

|February 17, 2025

概括

白质损伤在大脑小血管疾病 (CSVD) 患者中显著促进加速大脑衰老和认知衰退. 这些损伤调解了CSVD与大脑衰老和认知功能受损之间的关系.

科学领域:

神经成像是一种神经成像.
神经学神经学
老年学是指老年学的学科.

背景情况:

大脑小血管疾病 (CSVD) 是一种常见的疾病,影响老年大脑.
大脑的结构完整性对于认知功能至关重要.
CSVD对大脑衰老和认知的影响需要进一步研究.

研究的目的:

调查破坏结构完整性如何影响CSVD中大脑衰老和认知功能.
探索白质过强度和扩散异常在与CSVD相关的大脑衰老中的作用.

主要方法:

55名CSVD患者和42名对照人群接受了MRI (3D T1加权和扩散张力成像).
计算了相对大脑年龄 (RBA);结构完整性变量包括皮质厚度,体积,白质超强度 (WMH) 体积和骨架平均扩散率 (PSMD) 的峰值宽度.
用MMSE,TMT和听觉口头学习测试来评估认知功能;采用调解分析.

主要成果:

与对照组相比,CSVD患者的RBA显著增加.
白质损伤 (PSMD和WMH体积) 显著调解了CSVD和RBA之间的关联.
在CSVD患者中,较高的RBA与较差的认知得分相关,PSMD和WMH体积介导了RBA-认知功能关系.

结论:

白质损伤是CSVD中加速大脑衰老的关键调解者.
这些微观结构变化显著导致CSVD患者的认知能力下降.
针对白质完整性可能对于管理CSVD认知障碍至关重要.

关键词:

衰老的衰老衰老的衰老大脑小血管疾病是大脑小血管疾病.认知功能障碍认知功能障碍扩散张力成像的成像方法白质的超强度是白质的超强度.

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