超加工食品消费与炎症之间的关联:来自STANISLAS队列的见解
Lea Lin Chun Hu Xia1, Nicolas Girerd2, Zohra Lamiral1
1Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France.
European journal of nutrition
|February 17, 2025
概括
过度加工食品 (UPF) 的高摄入量与纤维细胞生长因子19 (FGF-19) 的较低水平有关. 这项研究探讨了UPF消费和炎症生物标志物之间的关联,发现与FGF-19有特定的负相关性.
科学领域:
- 营养科学 营养科学
- 生物化学 生物化学
- 公共卫生 公共卫生
背景情况:
- 高度超加工食品 (UPF) 消费与慢性疾病风险有关.
- 炎症是一种潜在的机制,但对UPF和炎症生物标志物的研究是有限的和不一致的.
研究的目的:
- 为了研究总体UPF消费和10个分类与78个循环炎症相关蛋白质之间的横截面关联.
- 澄清UPF摄入量与特定炎症标志物之间的关系.
主要方法:
- 利用了来自斯坦尼斯拉斯队列中的1594名成年参与者的数据.
- 使用NOVA分类估计的UPF消耗.
- 采用线性回归模型来分析UPF摄入量与循环蛋白之间的关联.
主要成果:
- 超加工食品 (UPF) 占总能量摄入量的28% (每天5.7份).
- 最初,15种与UPF摄入量相关的蛋白质;经过调整后,只有纤维细胞生长因子19 (FGF-19) 显示出显著的负相关性 (β = -0.02).
- 在UPF乳制品子类别和循环蛋白之间没有发现关联.
结论:
- UPF的消费与血清FGF-19水平有负面关联.
- 循环蛋白协会在不同的UPF子类别中有所不同.
- 需要进一步的研究来阐明UPF摄入量和炎症之间的复杂关系.
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