在患有癌症的患者中,Endostar与化疗联合使用的安全性
Dong-Xiao Wang1,2, Man Zhu2, Dai-Hong Guo2
1Department of Pharmacy, Peking University Shougang Hospital, Beijing, China.
Indian journal of cancer
|February 17, 2025
概括
现实世界的安全数据显示,Endostar与化疗相结合通常是安全的. 大多数不良事件都是轻微的,在中国患者中没有观察到新的意想不到的副作用.
科学领域:
- 在瘤学瘤学.
- 药物监督 药物监督 药物监督
- 临床研究 临床研究
背景情况:
- 现有研究表明,Endostar (endostar) 与化疗相结合是有益和安全的.
- 对于Endostar在组合治疗中的真实安全数据是有限的.
- 本研究评估了Endostar在接受化疗的中国患者群体中的实际安全性.
研究的目的:
- 评估Endostar在与化疗结合使用时的实际安全性.
- 在临床实践中识别与Endostar相关的任何意外不良事件.
- 分析实验室异常和特定并发症的发生率和严重程度.
主要方法:
- 在2006年至2017年期间,对825名接受Endostar和化疗治疗的患者进行了回顾性分析.
- 从医院信息系统 (HIS) 收集的数据.
- 使用常用术语标准对不良事件 (CTCAE) v4.0评估的不良事件 (AEs),包括实验室异常,出血和伤口并发症.
主要成果:
- 观察到贫血 (74.5%),血小板减少 (29.0%),异常白细胞计数 (54.5%),异常肝功能 (13.8%),以及肌氨酸增加 (1.2%).
- 没有确定Endostar相关的出血或伤口并发症.
- 大多数副作用是1级或2级;3级以上的异常白细胞计数与特定的癌症和化疗方案有关,但不是Endostar总剂量.
结论:
- 不良事件概况因瘤类型和化疗方案而异.
- 在这个现实环境中,没有发现Endostar相关的新的或意想不到的副作用.
- 总Endostar剂量与与化疗相结合时的严重血小板缩或异常白细胞计数的风险增加没有相关性.
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