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Updated: May 27, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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在服用高剂量长期阿片类药物的患者中使用布普伦诺芬,疼痛和阿片类药物:一项随机临床试验

William C Becker1,2, Karen H Seal3,4,5, David B Nelson6,7

  • 1VA Connecticut Healthcare System, West Haven, Connecticut.

JAMA internal medicine
|February 17, 2025
PubMed
概括

切换到布普伦诺芬并没有显著改善长期阿片类药物治疗患者的疼痛评分. 两组都实现了类似的疼痛缓解和阿片类药物剂量降低,布普伦诺芬采用率较低.

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