在自闭症儿童中使用Glutathione,维生素C和Cysteine具有破坏性行为:双盲,安慰剂控制的交叉试点研究
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Updated: May 27, 2025
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Strategies for Assessing Autistic-Like Behaviors in Mice
Published on: September 20, 2024
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Patricia Gail Williams1, Lonnie Sears1, Walter H Watson2
1Department of Pediatrics and Norton Children's Medical Group, School of Medicine, University of Louisville, Louisville, KY.
Journal of developmental and behavioral pediatrics : JDBP
|February 17, 2025
概括
谷氨治疗没有改善自闭症谱系障碍 (ASD) 的儿童的行为或生物测量. 积极的趋势可能是由于安慰剂效应,而不是干预本身.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 儿科 儿科 儿科
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,与氧化应激有联系.
- 谷氨是一种生物抗氧化剂,其在ASD中的使用是基于事证据.
- 这项研究调查了谷氨对ASD行为症状的安全性和有效性.
研究的目的:
- 评估谷氨和基于谷氨的组合疗法 (Trio) 在患有ASD的儿童中的疗效.
- 评估这些干预措施的安全性和耐受性.
- 收集与氧化应激相关的生物标志物的初步数据.
主要方法:
- 进行了一项双盲,安慰剂控制,随机交叉试验.
- 24名患有自闭症的儿童 (5-16岁) 每周接受安慰剂,谷氨或Trio静脉注射,持续8周,随后进行1周的洗和交叉.
- 行为测量和血谷氨水平在基线,洗期间和治疗后被评估.
主要成果:
- 治疗组之间没有观察到行为或生物测量的显著差异.
- 这些干预措施没有造成任何显著的不良副作用.
- 在研究期间,在所有组中,在一些指标上都出现了微小的改善.
结论:
- 谷氨或Trio疗法在改善ASD儿童的行为或生物测量方面没有表现出有效性.
- 观察到的积极趋势可能归因于安慰剂效应或减少与研究相关的焦虑.
- 需要进一步的研究来探索ASD的潜在治疗途径.
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