msp130基因的水平转移和甲动物生物化的演变
Macie M Chess1, Saoirse Foley2, Charles A Ettensohn1
1Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.
Genome biology and evolution
|February 17, 2025
概括
海洋动物很可能通过横向基因转移从细菌中获得关键骨基因. 这种古老的基因转移事件早于双胞胎,支持动物中化骨的进化.
科学领域:
- 进化生物学是进化的生物学.
- 分子生物学分子生物学
- 海洋生物学 海洋生物学
背景情况:
- 生物矿物化对海洋元动物至关重要,它涉及到复杂的遗传工具包.
- 像MSP130这样的基因的进化起源对于生物化至关重要,仍在争论中.
- 横向基因转移 (HGT) 被假设为获得这些基因的机制.
研究的目的:
- 为了调查甲动物MSP130蛋白质的基于HGT的起源.
- 提供植物遗传学和in silico证据,支持细菌获得MSP130基因.
- 了解MSP130基因在元动物中获得的进化时间表.
主要方法:
- 跨多种种类的msp130基因的遗传学分析.
- 在MSP130结构和功能的蛋白分析.
- 使用高质量的基因组组件进行比较基因组学.
主要成果:
- msp130基因在大多数生物化双边系中表现出重复.
- 鉴定了双边msp130基因特有的保留的内子-外子结.
- 双胞胎和细菌中的MSP130蛋白具有结构上的相似性,包括保存的桶形图案和Ca2+结合点.
结论:
- 祖先的msp130基因很可能起源于HGT,早于双边动物,但是在元动物中.
- MSP130蛋白质具有生物化的结构和功能特征.
- 细菌基因转移在化动物骨的进化中发挥了重要作用.
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