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在中国人群中,rs4673与血液压力对急性盐水输液的反应之间存在关联

Hongyi Wang¹, Xue Wang², Yan Tian³

¹Department of Hypertension, People's Hospital, Peking University, Beijing, China.

|February 17, 2025

概括

具有尼古丁胺胺氨基丁核酸酸盐氧化酶p22PHOX基因rs4673多态的T等位基因的个体在急性盐荷载后显示血压升高的减少. 这表明T等位基载体携带基本高血压的盐敏感性较低.

科学领域:

遗传学遗传学是一种遗传学.
心血管医学心血管医学
药物基因组学药物基因组学

背景情况:

基本高血压是一种复杂的疾病,受遗传和环境因素的影响.
盐敏感性,即对盐摄入的高血压反应,是高血压的关键决定因素.
尼古丁胺氨基二核酸酸氧化酶 (NADPH氧化酶) 酶复合体,特别是p22PHOX亚单元,在氧化应激和血压调节中发挥作用.

研究的目的:

调查p22PHOX基因中的rs4673多态化与中国患有基本高血压的患者对急性盐负荷的血压反应之间的关联.
为了确定rs4673的多态性是否会影响这个人群的盐敏感性.

主要方法:

一组159名患有基本高血压的中国患者接受了急性盐负荷测试,在4小时内注入2升正常盐水.
血压和心率在注射盐水之前和注射后3小时内被监测.
进行了rs4673多态 (CC,CT,TT) 的基因型鉴定.
统计分析包括千平方测试,学生t测试和多变量回归.

主要成果:

与CC基因型载体 (6.82 ± 11.65 mm Hg; P = .005) 相比,携带T等位基因 (CT或TT基因型) 的个体表现出系统血压 (0.26 ± 9.72 mm Hg) 的明显较低的增加.
透气血压变化在T等位基载体中也明显较低 (-3.35 ± 7.52 mm Hg) 与CC载体 (1.38 ± 7.62 mm Hg;P = .003).
与CC载体 (86.82%;P = .014) 相比,T等位基因携带者中较低的百分比 (66.67%) 在盐负载后经历了血压升高,这表明盐敏感性降低.

结论:

在p22PHOX基因中的rs4673多态性与基本高血压中的盐敏感性有关.
携带T等位基因可能会对盐引起的血压升高产生保护作用.
这些发现有助于了解高血压中盐敏感性的遗传基础.

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