麻醉对抗治疗性抑郁症患者的全球认知功能的电治疗相关损伤的影响
Léo Bernardoff1, Martin Blay, Dimitri Thellier2
1From the Vinatier Hospital Center, Bron, France.
The journal of ECT
|February 17, 2025
概括
选择麻醉剂 (propofol与etomidate) 进行电疗法 (ECT) 并没有影响治疗耐药抑郁症患者的认知功能变化. 这项研究发现,这两种麻醉剂之间的认知结果没有显著差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 麻醉学 麻醉学
背景情况:
- 电疗法 (ECT) 是主要抑郁障碍的常见治疗方法.
- 在ECT期间使用诸如普罗波福和埃托米达特之类的麻醉剂.
- 认知障碍是ECT已知的副作用,但麻醉剂的差异影响尚未得到充分研究.
研究的目的:
- 为了比较propofol与etomidate在ECT后对认知功能的影响.
- 评估麻醉选择对治疗结果对治疗耐药抑郁症患者的影响.
主要方法:
- 对75名患有严重抑郁症的患者进行了回顾性研究,这些患者接受了双边ECT.
- 在ECT前后使用蒙特利尔认知评估 (MoCA) 评估全球认知功能.
- 用蒙哥马利-阿斯伯格抑郁症评分表 (MADRS) 评估抑郁症严重程度.
主要成果:
- 埃托米达和普罗波组之间的MoCA得分变化没有显著差异.
- 两组之间在MADRS得分变化,缓解率或其他ECT参数中没有发现显著差异.
- 电脑电图危机持续时间的差异被注意到,但没有影响认知结果.
结论:
- 作为麻醉剂的普罗波福和埃托米达的选择不会显著影响患者接受ECT治疗治疗耐药性抑郁症的全球认知功能.
- 两种麻醉剂都没有在减轻ECT相关的认知副作用方面表现出明显的优势.
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