放射性标记产量取决于astatine-211的干燥后蒸衰变
Ellinor Hansson1, Chiara Timperanza2, Holger Jensen3
1Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden; Atley Solutions AB, 41327 Gothenburg, Sweden.
Nuclear medicine and biology
|February 17, 2025
概括
在干蒸后,Astatine-211 (211At) 的放射性化学产量随着时间的推移而下降,影响了向的α疗法. 在蒸后不久进行放射性标记对于保持高产量至关重要.
科学领域:
- 核化学 核化学 核化学
- 放射性药物化学 放射性药物化学
- 医学同位素 医学同位素
背景情况:
- 阿斯-211 (211At) 是针对性阿尔法疗法的关键同位素,目前正在进行临床试验.
- 了解211At在净化后的稳定性和放射性化学产量对于其临床应用至关重要.
研究的目的:
- 为了研究衰变时间对211At.At的放射化学产量的影响.
- 为了评估211At的产量变化,标记反应随着时间的推移干燥后蒸.
主要方法:
- 通过干蒸从石目标中净化211At.
- 在甲酸或作为干燥残留物中老化211At长达28小时 (3 x 10^12衰变).
- 放射性标记通过电友性脱和核友性替代,其产量由HPLC确定.
主要成果:
- 放射性化学产量随着干燥和酸盐211At的放射性衰变增加而下降.
- 当211At被储存在化物中时,电友性astatination显示出更快的产量下降.
- 即使在28小时后,增加的前体度也保持了超过80%的产量;氧化/减少剂和再溶解显示出潜在的缓解.
结论:
- 211的放射性化学产量在标记时随着时间的推移而下降干蒸后,无论储存方法如何.
- 为了确保高特异性活性,干蒸后应尽快使用211At进行放射性标记.
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