临床时代生物学:健康和疾病中的循环节律
Shizuka Tomatsu1, Sabra M Abbott1, Hrayr Attarian1
1Department of Neurology, Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Seminars in neurology
|February 17, 2025
概括
循环节律 (CRs) 调节基本的生理功能,并由大脑的主钟同步. CRs中断与许多健康问题有关,包括睡眠障碍,代谢综合征,情绪障碍和癌症.
科学领域:
- 时间生物学 时间生物学
- 神经内分泌学神经内分泌学
- 分子生物学分子生物学
背景情况:
- 昼夜节律 (CRs) 是一种内源的,可引诱的生物节律,调节生理功能.
- 上神核 (SCN) 作为哺乳动物的主钟,通过GABA和VIP等神经递质同步外围时钟.
- 核心时钟基因 (CLOCK,BMAL1,PERs,CRYs) 形成一个负反循环,控制细胞节律.
研究的目的:
- 探索昼夜节律调节的机制.
- 为了确定与昼夜干扰相关的临床条件.
- 讨论治疗干预措施和昼夜不整的更广泛的健康影响.
主要方法:
- 昼夜节律睡眠-清醒障碍 (CRSWDs) 的诊断依赖于患者病史,睡眠日记和动图.
- 治疗策略包括定时照射,黑激素激动剂和行为干预.
- 研究涉及分析CRs的遗传调节及其对各种生理系统的影响.
主要成果:
- 循环节障碍与CRSWD,不孕不育,代谢综合征 (肥胖,糖尿病),情绪障碍和神经退行性疾病有关.
- 被扰乱的昼夜节律可能会加剧,并增加由于免疫系统调节失调而导致的感染风险.
- 红细胞结核损伤通过影响DNA修复,细胞亡和细胞循环调节,影响癌症的发展和对化疗的反应.
结论:
- 循环节律调节对于整体健康至关重要.
- 昼夜节律的失调有助于广泛的疾病.
- 针对昼夜调整的治疗策略显示出对管理各种健康状况和提高治疗疗效的希望.
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