通过实施尿素/肌素比率预警机制,尽量减少在自动化实验室分析中的血清肌素干扰
Hui Ding1, Jun Shao2, Hua Cao1
1Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
Clinica chimica acta; international journal of clinical chemistry
|February 17, 2025
概括
自动尿素/肌素比 (UCR) 查准确地识别了药物干扰的血清肌素 (Cr) 测量. 这种方法提高了Cr试验的精度和临床可靠性,而不会影响实验室的工作流程.
科学领域:
- 临床化学 临床化学
- 实验室自动化 实验室自动化
- 分析毒理学分析毒理学
背景情况:
- 血清肌素 (Cr) 测量对于临床诊断至关重要,但可能会受到药物干扰的影响.
- 现有的检测方法需要改进,以提高精度和临床意义.
- 实验室自动化有助于提高生物化学分析的准确性和效率.
研究的目的:
- 通过实验室自动化改进血清肌素 (Cr) 测量方法.
- 采用尿素/肌素比率 (UCR) 来检测和减轻药物干扰.
- 提高血清Cr检测的精度和临床意义.
主要方法:
- 血清Cr被测量使用西门子萨尔科辛氧化酶酶 (SOE) 试验.
- 一个大数据集 (近200万条记录) 用于血清UCR分析.
- 自动化系统发现了异常的UCR值,触发了西门子Jaffe测定和对LC-IDMS/MS的验证的重新评估.
主要成果:
- 血清UCR的参考区间是从0.047到0.143.3建立的.
- 与LC-IDMS/MS.相比,西门子Jaffe试验显示了3.10%的平均偏差.
- 这种改进的测定准确地反映了具有特定药物干扰的样本中的真实Cr水平.
结论:
- 基于UCR的自动查有效地识别了与药物相关干扰的样本.
- 这种方法降低了临床风险,并确保了血清Cr测量的准确性.
- 该协议保持了实验室工作流的生产力,同时提高了测试准确性.
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