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Updated: May 27, 2025

Procedure to Evaluate the Efficiency of Flocculants for the Removal of Dispersed Particles from Plant Extracts
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Procedure to Evaluate the Efficiency of Flocculants for the Removal of Dispersed Particles from Plant Extracts

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在干颗粒处理过程中使用灰盒模型整合机器学习模型和约翰逊模型进行规模独立的固体分数预测

Kanta Sato1, Shuichi Tanabe2, Keita Yaginuma2

  • 1Formulation Technology Research Laboratories, Daiichi Sankyo Co., Ltd., 1-12-1, Shinomiya, Hiratsuka 2540014 Kanagawa, Japan; Department of Informatics, Kyoto University, Yoshida-Honmachi, Sakyo-ku 6068501 Kyoto, Japan.

International journal of pharmaceutics
|February 17, 2025
PubMed
概括

这项研究引入了一种新的灰色盒模型,用于预测滚筒压缩中的固体分数. 该模型克服了约翰逊模型的局限性,通过估计关键的预巩固性质,改善产品质量控制.

关键词:
干燥颗粒化干燥颗粒化混合动力模型 混合动力模型约翰逊的模型模型过程建模的过程建模.固体分数 固体分数

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Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
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Model Approaches for Pharmacokinetic Data: Compartment Models

Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
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End Point Prediction: Gran Plot01:07

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Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

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Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

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This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
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