麦β-葡萄糖增强了肠道屏障功能,并在自然衰老的小鼠中维持了肠道平衡
Renzhi Huang1, Jia Zhang1, Maozhong Sun1
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Biointerface and Biodetection, and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
International journal of biological macromolecules
|February 17, 2025
概括
麦β-葡萄糖 (BG) 补充剂通过加强肠道屏障和减少炎症,改善了老年小鼠的肠道健康. 这种营养干预支持肠道微生物群平衡,并增强有益的短链脂肪酸的产生.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 衰老与肠道屏障功能受损,慢性炎症和肠道微生物群多样性减少有关.
- 这些与年龄相关的变化可能会对整体健康和福祉产生负面影响.
研究的目的:
- 为了研究麦β-葡萄糖 (BG) 对自然衰老小鼠肠道平衡的保护作用.
- 确定BG对肠道屏障完整性,炎症和肠道微生物群组成的影响.
主要方法:
- 老年小鼠每天服用400毫克/公斤的麦β-葡萄糖 (BG).
- 评估了肠道粘膜结构,屏障功能标记物 (ZO-1,ocludin,claudin),炎症性细胞因子 (TNF-α,IL-6,IL-1β) 和抗氧化剂反应.
- 分析了肠道微生物组合和短链脂肪酸 (SCFA) 水平,包括酸盐,酸盐和酸盐衍生的GABA.
主要成果:
- BG干预调节了肠粘膜结构和增强了机械屏障功能.
- 在老年小鼠中,BG显著降低了慢性炎症的标志物,并改善了抗氧化剂反应.
- 葡萄糖补充剂增加了有益的肠道细菌 (例如,Bacteroidota,Faecalibacterium) 和升高的SCFA水平 (乙酸,酸,GABA).
结论:
- 麦β-葡萄糖 (BG) 证明了在调节肠道屏障稳定和肠道微生物群的治疗潜力.
- BG通过有益的微生物促进SCFA的产生,支持肠道健康.
- 这些发现为开发营养策略提供了宝贵的见解,以减轻与年龄相关的肠道功能障碍.
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