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Types of Step-Growth Polymers: Polyesters01:20

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
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The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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相关实验视频

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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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基于伊塔康酸盐的可降解聚材料的抗纤维功能

Zachary S C S Froom1, Kyle Medd1, Brenden P Wheeler1

  • 1School of Biomedical Engineering, Faculties of Medicine and Engineering, Dalhousie University, Halifax, NS B3H 4R2, Canada.

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概括

这项研究开发了一种新的聚合物输送系统,用于伊塔科纳酸 (IA) 治疗纤维性疾病. 可生物降解的聚合物释放IA,有效降低亲纤维细胞活性,并提供了一个有前途的新疗法策略.

关键词:
药物输送是药物输送的过程.纤维化 纤维化免疫代谢的免疫代谢.这是一种炎症炎症炎症炎症.聚聚是什么意思 聚聚

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Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
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科学领域:

  • 生物材料科学 生物材料科学
  • 细胞生物学 细胞生物学
  • 药物运输 药物运输 药物运输

背景情况:

  • 病理性纤维化是一种慢性疾病,由过度的细胞外基质沉积驱动.
  • 目前的抗纤维菌疗法受到纤维菌微环境中巨细胞和纤维细胞之间的复杂信号传递的限制.

研究的目的:

  • 通过一种新型可生物降解聚合物输送的伊塔科纳酸 (IA) 的抗纤维素潜力进行调查.
  • 在纤维性疾病中准巨细胞-纤维细胞轴,以改善治疗结果.

主要方法:

  • 将伊塔科纳酸 (IA) 纳入可生物降解聚聚合物 (poly[IA-DoD]) 进行持续局部释放.
  • 聚 (IA-DoD) 降解和释放动态的表征.
  • 在小鼠巨细胞和人类皮肤纤维细胞上对多 (IA-DoD) 降解产物的评估.

主要成果:

  • 聚 ((IA-DoD) 证明了IA和IA含有寡合物的持续释放.
  • 聚 ((IA-DoD) 调节的益纤维细胞巨细胞反应的降解产物.
  • 纤维细胞的增殖和α-光滑肌肉的活性表达被聚合物降解产物减少.

结论:

  • 聚 ((IA-DoD) 有效地针对纤维化中的关键细胞参与者,破坏纤维化循环.
  • 这种基于聚合物的输送系统为治疗纤维性疾病提供了一个有希望的策略.