老年营养风险指数与尿道癌患者的生存结果之间的关联:更新的元分析
I-Wen Chen1,2, Jui-Hung Hsu3, Jing-Cyuan Huang4
1Department of Anesthesiology, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
BMJ open
|February 17, 2025
概括
低老年营养风险指数 (GNRI) 与尿道癌患者的存活率降低有关. 这个指数可以帮助预测结果,并指导临床决策,以改善患者护理.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 营养状况对于癌症患者的治疗结果至关重要.
- 老年营养风险指数 (GNRI) 是评估营养风险的工具.
- 它在泌尿癌的预后价值需要全面评估.
研究的目的:
- 进行一项元分析,评估GNRI与泌尿癌患者的存活率之间的关联.
- 综合来自GNRI和长期生存结果的观察性研究的证据.
主要方法:
- 观察性研究的系统审查和元分析.
- 在Medline,EMBASE,Google Scholar和Cochrane图书馆进行文学搜索.
- 使用纽卡斯尔-太华尺度数据提取和质量评估;通过GRADE证据的确定性.
主要成果:
- 包括17项研究,包括8816名患者;其中15项具有偏差的低风险.
- 低GNRI显著与整体存活率差 (HR 2.6),癌症特异性存活率 (HR 2.65),无复发性存活率 (HR 1.47) 和无进展性存活率 (HR 1.86) 相关.
- 对OS/PFS的证据确定性低,对CSS/RFS的证据确定性很低;与随访时间和样本大小相关的异质性.
结论:
- 低GNRI是尿道癌症生存率差的重要预测因素.
- 在临床实践中,GNRI显示出作为一种有价值的预后工具的潜力.
- 需要进一步的研究,以便在不同种群中验证并探索生物机制.
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