卧卧姿势阻塞性睡眠呼吸暂停在儿童和成年人的性别和年龄差异
Leping Li1,2, Min Shi3, David M Umbach3
1Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. leping@med.unc.edu.
Sleep & breathing = Schlaf & Atmung
|February 17, 2025
概括
卧底位置阻塞性睡眠呼吸暂停 (POSA) 在男性和女性中随着年龄的增长而增加. 然而,POSA在男性中更为普遍,特别是在40至75岁之间.
科学领域:
- 睡眠医学 睡眠医学
- 呼吸系统生理学 呼吸系统生理学
- 老年学是指老年学的学科.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是睡眠期间常见的呼吸系统疾病.
- 定位性OSA (POSA) 是一种亚型,其中睡眠呼吸暂停事件主要发生在卧卧的位置.
- 了解POSA的年龄和性别差异对于诊断和管理至关重要.
研究的目的:
- 为了研究卧卧位置阻塞性睡眠呼吸暂停 (POSA) 的与年龄相关的轨迹.
- 为了分析POSA在整个生命周期中的患病率和严重性的性别特异性差异.
- 在男性和女性中识别具有高POSA风险的年龄组.
主要方法:
- 对来自13,144名 (2-103岁) 个体的多睡眠学数据的回顾性分析.
- 一般化的线性混合效应模型来评估位置特定的呼吸暂停-呼吸暂停指数 (AHI).
- 后勤回归以确定POSA和专属POSA个体的比例.
主要成果:
- 在大多数5岁以上的个体中,supine AHI超过横向AHI.
- 卧式与侧面AHI的比例随着年龄的增长而增加,特别是在男性30-35岁,女性50-55岁之后.
- 随着年龄的增长,POSA的患病率增加到30-35岁,然后稳定下来,男性年龄在40-75岁之间患病率更高.
结论:
- 随着年龄的增长,POSA的患病率在两性都会上升.
- 一般来说,女性的POSA患病率较低,但在65岁以后继续增加.
- 年龄和性别是影响POSA发展和严重程度的重要因素.
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