评估涉及生物打印的临床和观察性试验环境:一个范围审查
Yumi Briones1,2, Beatrice Pascua3,4, Narra Tiangco3,5
1Biomedical Research Unit, Clinical and Translational Research Institute, The Medical City, Ortigas Avenue, Pasig City, 1600, Metro Manila, Philippines. Yumi.Briones@nyulangone.org.
3D printing in medicine
|February 17, 2025
概括
生物打印正在临床研究中出现,重点是针对癌症和再生的患者特定组织. 需要进一步的标准化来跟踪其从实验室到诊所的翻译.
科学领域:
- 组织工程是组织工程.
- 再生医学是一种再生医学.
- 临床试验 临床试验
背景情况:
- 生物打印,一个关键的组织工程技术,正在向复杂的临床用途前进.
- 关于生物打印技术超越临床前研究的转型的证据有限.
- 本综述评估了生物打印的临床研究环境.
研究的目的:
- 评估生物打印在临床研究中的现状.
- 确定生物打印应用和试验设计的趋势.
- 为了绘制生物打印从临床前到临床阶段的进展.
主要方法:
- 搜索了五个试验数据库和两个注册表.
- 生物打印是一种生物打印.
- 和各种变体.
- 包括符合生物打印定义的英语试验.
- 综合数据进行叙述.
主要成果:
- 11项试验 (2016-2023) 符合纳入标准,其中中国处于领先地位.
- 四项试验涉及植入生物打印组织 (例如血管,耳朵).
- 七项试验集中在用于癌症研究的体外模型上.
结论:
- 生物打印目前处于临床研究的早期阶段,针对癌症的精确医学和再生.
- 标准化报告对于透明度和可复制性至关重要.
- 这一审查为监测生物打印的临床转化提供了一个框架.
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