整合替代疗法来克服瘤中的化疗耐药性
Sana S Alqarni1, Najeeb Ullah Khan2
1Department of Clinical Laboratory Science, College of Applied Medical Science, King Saud University, 11421, Riyadh, Saudi Arabia.
Molecular biology reports
|February 17, 2025
概括
化疗耐药性是癌症治疗中的一个主要障碍. 本综述探讨了免疫疗法和草药治疗等替代疗法,以克服耐药性并改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 癌症治疗方法 癌症治疗方法
- 药物耐药性 药物耐药性 药物耐药性
背景情况:
- 瘤中的化疗耐药性构成了重大的临床挑战.
- 机制包括遗传突变,药物排放,新陈代谢改变和瘤微环境适应.
- 这些因素限制了治疗的有效性,并导致瘤复发.
研究的目的:
- 对克服化疗耐药性的替代疗法进行审查.
- 突出新兴策略及其有效率.
- 讨论替代疗法与传统治疗方法的整合.
主要方法:
- 关于替代癌症治疗策略的文献综述.
- 对各种替代疗法的疗效率进行分析.
- 讨论癌症治疗方面的挑战和未来方向.
主要成果:
- 替代疗法显示高疗效:草药 (90%),光动力疗法/低温 (86-99%),免疫疗法 (80%),基因疗法 (67-80%),表观遗传疗法 (51-89%).
- 针对性疗法 (58-64%),激素疗法 (22-61%),益生菌 (34-90%),代谢疗法 (>50%),基于微生物组的疗法 (50%) 和纳米技术 (50-67%) 也在探索中.
- 将这些与传统治疗相结合,可以提高治疗效率和患者的治疗结果.
结论:
- 分子诊断,液体活检和生物标志物的进步对于监测耐药性和指导治疗至关重要.
- 解决瘤异质性和缺乏预测生物标志物的问题至关重要.
- 扩大临床试验对于验证新疗法和改善患者存活率至关重要.
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