在高血压患者中,生命必需8和死亡率之间的关联
Min Lin1, Xiongbiao Lin2, Wenwen Chen1
1Shengli Clinical Medical College of Fujian Medical University, Fuzhou, P. R. China.
Scientific reports
|February 17, 2025
概括
更高的生活必需品8 (LE8) 评分显著减少心血管疾病 (CVD) 和高血压患者的全因死亡率. 改善饮食和睡眠等LE8指标是改善健康结果的关键.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 预防医学 预防医学
背景情况:
- 美国心脏协会推出了"生命必需8" (LE8) 评分,以评估心血管健康.
- 高血压是心血管疾病 (CVD) 和死亡的主要危险因素.
- 了解LE8得分对高血压患者死亡率的影响对于公共卫生战略至关重要.
研究的目的:
- 调查LE8总得分及其各个组成部分与所有原因和心血管疾病死亡率之间的关联.
- 评估LE8得分对高血压成年人死亡风险的预测价值.
- 确定最显著影响该人口死亡率的特定LE8指标.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) (2005-2018) 的10,556名高血压成年人的数据.
- 采用考克斯回归分析来评估LE8得分与6.75年的中位随访后死亡结果之间的关系.
- 进行了子组分析,以探索个别LE8指标对死亡率的影响.
主要成果:
- 具有高LE8分数 (≥75) 的患者表现出明显较低的全因和心血管疾病死亡率 (P < 0.001).
- 与低得分相比,高LE8得分与所有原因和心血管疾病死亡率降低40%的风险有关.
- 在LE8得分和死亡风险之间观察到线性反向关系,潜在的值效应约为60点.
结论:
- 在高血压患者中,LE8得分与全因和心血管疾病死亡率相反相关.
- 针对LE8组件 (饮食,睡眠,体力活动,血糖) 的干预措施可以有效降低高血压患者的死亡率.
- LE8评分是风险分层和指导高血压群体的预防策略的宝贵工具.
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