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用嗅觉和味觉大脑连接网络预测酒精摄入模式

Khushbu Agarwal^1,2, Shefali Chaudhary³, Dardo Tomasi⁴

¹Section of Sensory Science and Metabolism, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA. khushbu.agarwal@nbrc.ac.in.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

|February 17, 2025

概括

与味觉和嗅觉相关的大脑连接模式可以预测年轻成年人的酒精摄入量. 这些发现可能有助于早期查和针对酒精使用障碍的个性化干预.

科学领域:

神经科学是一个神经科学.
成研究研究成研究
神经成像是一种神经成像.

背景情况:

渴望酒精通常是由味道和气味等感官线索引发的.
大脑网络连接与这些化学传感驱动的触发器有关.

研究的目的:

调查与味觉和嗅觉相关的大脑连接模式是否可以预测年轻成年人的酒精消费.
为了确定与酒精摄入量指标相关的特定功能连接体.

主要方法:

利用了来自人类结合体项目 (HCP) 年轻成人队列 (n=1003) 的休息状态功能磁共振成像 (fMRI) 数据.
分析了100个独立组件的功能连接体,将它们与味道和气味得分相关联.
应用了错误发现率 (FDR) 校正 (本杰明-霍赫伯格方法) 和一般线性模型来预测酒精摄入量.

主要成果:

确定了41个与气味相关的和25个与味道相关的大脑连接,在FDR校正后显著预测酒精摄入量.
视觉-视觉连接预测了葡萄酒消费,而腹部注意网络 (VAN) 连接预测了整体酒精摄入量.
预测模型显示出很强的准确性 (F1评分为0.74的气味,0.71的味道).

结论:

与嗅觉和味觉感知相关的特定大脑连接模式可以预测年轻人的酒精消费行为.
这些发现表明,在早期查和针对酒精使用障碍 (AUD) 的个性化干预中,可能存在与味道和气味相关的大脑连接.
建议进行纵向研究,以进一步评估这些对AUD风险和治疗的预测模式.

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