与代谢功能障碍相关的脂肪性肝病增加了年轻成年人的心血管疾病风险
Goh Eun Chung1,2, Su Jong Yu2, Jeong-Ju Yoo3
1Department of Internal Medicine and Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea.
Scientific reports
|February 17, 2025
概括
与代谢功能障碍相关的脂肪肝疾病 (MASLD) 在年轻人中显著增加心血管疾病 (CVD) 风险. 对MASLD的早期干预对于预防心脏病在这个人口群体中至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MASLD) 与心血管疾病 (CVD) 有关.
- 马斯尔德对年轻成年人心血管疾病风险的影响仍然被低估.
- 年轻人越来越多地受到代谢障碍的影响.
研究的目的:
- 评估MASLD和年轻成年人中发生的心血管疾病之间的关联.
- 在这个年龄组中识别受MASLD影响的特定心血管疾病亚型.
- 探索MASLD相关心脏病风险的亚组变化.
主要方法:
- 基于人口的队列研究,使用韩国国家医疗保险服务数据 (2009-2012).
- 包括20-39岁的成年人,平均随访时间为10.6年.
- 按脂肪肝指数≥30定义的MASLD,没有其他肥胖症原因加上心脏代谢风险因素.
主要成果:
- 在5,666,728名参与者的25.3%中,MASLD存在.
- MASLD与重大心血管不良事件的累积发病率显著增加相关 (P < 0.001).
- 在MASLD患者中,心肌梗塞 (1.23),缺血性中风 (1.12),充血性心力衰竭 (1.18) 的调整后危险比率较高.
结论:
- MASLD显著增加了年轻成年人的心血管疾病风险.
- 在MASLD中,心血管疾病风险增加在女性和肥胖个体中更为明显.
- 建议在年轻人中对MASLD进行早期干预,以减轻未来的心血管疾病风险.
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