肉症和肝硬化患者的最小肝脑病变之间的关系:一项前性观察性研究
Wasit Wongtrakul1,2, Wimolrak Bandidniyamanon1, Phunchai Charatcharoenwitthaya3
1Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
BMC gastroenterology
|February 18, 2025
概括
肌肉质量损失的萨尔科佩尼亚在肝硬化患者中很常见,并且显著增加了最小肝脑病变 (MHE) 的风险. 对这些患者的MHE进行管理,评估肉症至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 肌肉生理学 肌肉生理学
背景情况:
- 标志着肌肉质量和功能丧失的萨尔科佩尼亚,在肝硬化中越来越多地被认可.
- 它与包括最小肝脑病变 (MHE) 在内的不良结果的关联值得研究.
研究的目的:
- 在肝硬化患者中调查缩症和MHE之间的关联.
- 为了确定萨科佩尼亚是否在这个人群中是MHE的独立风险因素.
主要方法:
- 预期招收患有肝硬化的门诊患者.
- 使用2019年亚洲麻症工作组标准进行麻症评估.
- 通过心理测量肝脏脑病症评分 (Psychometric Hepatic Encephalopathy Score) 进行MHE诊断.
主要成果:
- 在210名肝硬化患者中,有25.7%的患者患有肉类;17.6%的患者患有MHE.
- 患有MHE的患者 (45.9%) 与没有MHE的患者 (21.4%) 相比,sarcopenia的患病率显著更高.
- 多变量分析显示,皮病 (aOR 3.29) 和严重的皮病 (aOR 3.64) 独立地与MHE相关.
结论:
- 萨科佩尼亚是肝硬化患者中普遍存在的疾病.
- 萨科佩尼亚显着与患MHE的风险增加有关.
- 常规评估的肉可能有助于减轻MHE风险在肝硬化管理.
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