血液学标记作为PLHIV肺结核的预测工具:印度古吉拉特州的一项回顾性队列研究
Yogesh M1, Roshni Vamja1, Parth Anilbhai Parmar2
1Department of Community Medicine, Shri M P Shah Government Medical College, Jamnagar, Gujarat, India.
BMC infectious diseases
|February 18, 2025
概括
血液学参数如单细胞-淋巴细胞比率 (MLR) 和贫血可以预测艾滋病毒感染者 (PLHIV) 结核病 (TB). 升高的MLR或贫血显著增加结核病风险,有助于早期检测.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 对艾滋病毒感染者 (PLHIV) 构成重大健康威胁.
- 在PLHIV中早期诊断和治疗结核病至关重要.
- 正在探索血液学参数作为结核病预测和监测的潜在生物标志物.
研究的目的:
- 评估血液学参数在预测PLHIV患者结核病中的有效性.
- 为了确定与此群体结核病风险增加相关的特定血液学标志物.
主要方法:
- 印度古吉拉特州一个ART中心的回顾性队列研究 (2018年1月 - 2024年3月).
- 血液学参数的分析包括血红蛋白,血小板计数,WBC差异,单细胞-淋巴细胞比率 (MLR) 和中性粒细胞-淋巴细胞比率 (NLR).
- 考克斯的比例危险模型和卡普兰-梅尔生存分析被用来评估关联.
主要成果:
- 在810名PLHIV患者中,202名 (25%) 被诊断为结核病患者.
- 结核病的PLHIV患者的贫血 (91.6%),白细胞病 (16.3%) 和中性恋 (25.2%) 的比率更高.
- 单细胞-淋巴细胞比率 (MLR) >0.23与结核病风险增加5.44倍,贫血风险增加4.37倍有关,独立于其他因素.
结论:
- 血液学参数,特别是MLR和贫血,是PLHIV结核病的强有力的预测因素.
- 这些具有成本效益的标记物可以帮助早期发现结核病并对PLHIV进行风险分层.
- 将这些标记物整合到查方案中可能会改善患者的治疗结果,尤其是在资源有限的环境中.
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