该TANGO-DM随机对照试验研究协议:根据世卫组织2013年或世卫组织1999年值诊断的妊娠糖尿病的治疗结果
Doortje Rademaker1,2, Leon de Wit3, Anne van der Wel4,5
1Department of Obstetrics and Gynecology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands. d.rademaker@amsterdamumc.nl.
BMC pregnancy and childbirth
|February 18, 2025
概括
这项研究调查了新的妊娠期糖尿病 (GDM) 诊断标准是否会减少孕期婴儿的大. 在TANGO-DM试验中,使用2013年世卫组织标准对比标准护理的强化GDM治疗.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 孕期糖尿病 (GDM) 影响全球7-10%的怀孕,随着血糖的增加,风险会增加.
- 新的2013年世卫组织GDM诊断标准使用的葡萄糖值不同于1999年的标准.
- 基于新标准的GDM治疗对母亲和婴儿的结果的影响尚不清楚.
研究的目的:
- 评估按照2013年世卫组织标准进行的密集性GDM治疗是否能减少与1999年标准的治疗相比,孕期大婴儿 (LGA) 的发生率.
- 评估二次结果,包括孕产妇,产科和新生儿并发症,生活质量和成本.
主要方法:
- TANGO-DM试验是一个开放的,多中心的随机对照试验.
- 怀孕妇女 (16-32周怀孕) 具有不一致的GDM诊断标准 (1999年与2013年WHO) 被随机分类.
- 干预组接受了密集的GDM治疗 (饮食,监测,必要时服用药物),而对照组接受了标准的产科护理.
主要成果:
- 主要结局:婴儿出生体重>第90百分位数 (LGA) 的减少.
- 二次结果:产妇和新生儿并发症,产科干预,生活质量和医疗保健费用.
- 研究发现LGA从16%降低到10%与1032名参与者.
结论:
- 这项TANGO-DM试验旨在提供有关2013年世卫组织GDM诊断标准有效性的高水平证据.
- 结果将为临床实践提供有关GDM管理及其对围产期结果和医疗保健成本的影响的信息.
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