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Updated: May 27, 2025

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
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腹膜内注射编码interleukin-12的mRNA用于腹膜癌症的免疫治疗

Leire Arrizabalaga1,2, Claudia Augusta Di Trani1,2, Myriam Fernández-Sendin1,2

  • 1Program of Immunology and Immunotherapy, Cancer Center Clínica, Cima Universidad de Navarra, Universidad de Navarra (CCUN), Avenida Pio XII, 55, Pamplona, Spain.

Journal of nanobiotechnology
|February 18, 2025
PubMed
概括

这项研究表明,使用cationic化合物的腹膜内mRNA输送有效地向腹膜癌症中的巨细胞. 这种方法增强了抗瘤免疫力,并在临床前模型中改善了生存率.

关键词:
癌症免疫疗法癌症免疫疗法互乐金-12是其中一种.地方地区治疗.腹腔周周癌症的发生.它们是mRNARNA.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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