一系列自然语言处理用于从电子健康记录中预测瘤反应评估和生存曲线
Toshiki Takeuchi1, Hidehito Horinouchi2, Ken Takasawa3
1, Xcoo, Inc. Hongo-Sanchome TH Bldg., 6F, 2-40-8, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. take@xcoo.jp.
BMC medical informatics and decision making
|February 18, 2025
概括
这项研究开发了一种自然语言处理方法,通过电子健康记录 (EHR) 来预测肺癌治疗结果. 该方法通过分析患者数据来分析瘤反应和生存曲线来支持临床研究.
科学领域:
- 在瘤学瘤学.
- 医疗信息学 医疗信息学
- 自然语言处理自然语言处理.
背景情况:
- 非结构化的电子健康记录 (EHR) 包含了癌症研究的宝贵临床信息.
- 日本国家癌症中心医院 (NCCH) 有大量关于胸部恶性瘤的数据.
- 来自电子健康记录的医院和研究数据的综合分析是有限的.
研究的目的:
- 开发一种方法来预测肺癌患者的瘤反应和生存曲线.
- 利用自然语言处理 (NLP) 来提取和分析临床数据.
- 增强EHR在癌症研究和临床研究中的实用性.
主要方法:
- 开发了一种基于规则的算法,使用药物和治疗方案字典来预测治疗持续时间.
- 将监督学习应用于放射学报告,以预测瘤反应和进展性疾病 (PD) 日期.
- 利用来自716种肺癌治疗的EHR进行模型培训和测试.
主要成果:
- 对瘤反应和PD日期的个体预测不是非常准确的.
- 预测的生存曲线与实际的生存曲线非常接近.
- 该方法表现出足够的性能来支持数据库构建和临床信息提供.
结论:
- 开发的NLP方法显示了支持医生和临床研究协调员 (CRC) 的潜力.
- 它有助于从电子健康记录中提取临床信息,帮助研究人员识别临床研究机会.
- 虽然没有完全自动化,但该系统为癌症研究提供了宝贵的支持.
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