达拉图穆马布无敏化:在经验POEMS综合征的新方法
Rosalaura Villarreal-González1, Nataly Flores-García2, Diana Cadenas-García1
1Faculty of Medicine, Oncology Service, University Hospital "Dr José Eleuterio González", Autonomous University of Nuevo León, Monterrey, Mexico.
概括
对达拉图穆马布的过敏反应可能会发生,但一种脱敏方案允许患有POEMS综合征的患者安全地接受CD38抗体. 这种方法使耐火性疾病患者的持续治疗成为可能.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 达拉图马布是一种向CD38的单克隆抗体,在45-48%的患者中引起了输液相关反应.
- 需要停止治疗的严重过敏反应 (HSR) 在接受达拉图穆马布的患者中发生的比例很小.
研究的目的:
- 描述在患有POEMS综合征且出现严重过敏反应的患者中成功的达拉图穆马布脱敏方案.
- 评估达拉图穆马布重新引入的新型脱敏治疗方案的安全性和有效性.
主要方法:
- 一名37岁的男性患有复发的POEMS综合征,接受了静脉注射达拉图马布.
- 患者在初始输液后不久经历了严重的 (布朗III) 过敏反应.
- 在随后的输液中,在5.67小时内实施了3袋,12步脱敏方案,用于随后的输液.
主要成果:
- 在没有任何过敏反应的情况下,进行了8次成功的达拉图穆马布脱敏治疗.
- 脱敏协议使得达拉图马布治疗的安全重新开始和继续成为可能.
- 这一案例增加了关于严重过敏反应的达拉图穆马布脱敏化有限的已公布数据.
结论:
- 达拉图穆马布无敏化是POEMS综合征患者的可行策略,这些患者经历了严重的过敏反应.
- 这种方法使得达拉图马布的持续治疗更容易,即使在严重过敏反应的情况下也是如此.
- 对达拉图穆马布 (daratumumab) 等单克隆抗体的标准化无敏化协议进行进一步的研究是有必要的.
更多相关视频
09:39Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
Published on: January 27, 2014
12.6K
10:18Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
Published on: July 7, 2023
1.1K
相关概念视频
Tumor Immunotherapy
463
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
463
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
