纳多法拉基因 firadenovec-vncg对于药剂师的实际使用
Seth D Holler1, Sara Moran Smith2
1WVU Medicine, Morgantown, WV, USA.
概括
药剂师在治疗Bacillus Calmette-Guérin (BCG) 无反应的非肌肉侵入性膀癌 (NMIBC) 中发挥着至关重要的作用. 教育和意识是优化其安全有效的临床使用的关键.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 没有对Bacillus Calmette-Guérin (BCG) 治疗反应的非肌肉侵入性膀癌 (NMIBC) 是一个重大的临床挑战.
- 纳多法拉基尼 (Nadofaragene firadenovec) 是这种患者群体的一个新兴治疗选择.
- 优化新疗法的使用需要对其在多学科护理团队中的应用有全面的了解.
研究的目的:
- 为药剂师概述一个实用的框架,以确保纳多法拉基尼 firadenovec.安全有效的管理.
- 详细说明药剂师在管理BCG不响应NMIBC的患者中的作用.
- 在整个患者护理连续过程中突出纳多法拉基尼 (nadofaragene firadenovec) 的关键考虑因素.
主要方法:
- 本综述综合了临床研究数据和来自机构环境的实践经验.
- 它侧重于药剂师在患者护理中的参与,从处理到咨询.
- 讨论的关键方面包括作用机制,管理,不良事件和处置.
主要成果:
- 药剂师是纳多法拉基因治疗的多学科团队的组成成员.
- 药剂师的关键职责包括了解药物的特征,为患者提供咨询,以及管理潜在的不良事件.
- 处理,储存,管理和处置的实际考虑对于安全使用至关重要.
结论:
- 药剂师处于有利地位,可以提高高风险NMIBC中纳多法拉基因firadenovec的有效利用率.
- 提高药剂师的意识和有针对性的教育将进一步优化患者的治疗结果.
- 药剂师的作用对于导航BCG不响应NMIBC的这种向治疗的复杂性至关重要.
相关概念视频
01:17Drug Nomenclature
1.6K
During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that...
1.6K
01:29Drug Delivery: Parenteral Route
374
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
374
01:18Drug Delivery: Enteral Route
372
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
372
01:19Pharmacovigilance
768
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
768
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
85
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
85
01:20Volume of Distribution
92
The apparent volume of distribution (Vd) is a crucial pharmacokinetic parameter representing the hypothetical body fluid volume into which a drug disperses. It is calculated based on the total amount of drug in the body (estimated from the administered dose and bioavailability) divided by the plasma drug concentration. The total amount of drug in the body does not directly refer to the dose given but is derived by accounting for absorption, distribution, metabolism, and excretion processes.
92