来自食物的酒精脱酶激活:生产,鉴定,结构-活性关系和作用机制
Mengyao Li1, Junjia Zhang2, Lilin Cheng3
1National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Critical reviews in food science and nutrition
|February 18, 2025
概括
来自食物的生物活性在激活酒精脱酶 (ADH) 方面表现有前途,有助于酒精代谢. 本综述总结了准备,机制,并确定了对这些ADH激活的未来研究的知识差距.
科学领域:
- 生物化学 生化学
- 食品科学 食品科学 食品科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 过度饮酒对健康构成重大风险.
- 酒精脱酶 (ADH) 对于酒精代谢至关重要.
- 食品衍生生物活性被认为具有对代谢的调节作用.
研究的目的:
- 审查ADH激活的制备,分离,净化和鉴定.
- 批判性地讨论这些的结构-活性关系和作用机制.
- 识别知识缺口,并为未来的研究提供参考.
主要方法:
- 文献综述专注于ADH激活的研究.
- 制备和识别技术的总结.
- 分析结构-活动关系和作用机制.
主要成果:
- 获得ADH激活的方法的初步总结.
- 关于结构-活动关系和机制的批判性讨论.
- 确定当前研究的局限性.
结论:
- 来自食物的生物活性代表了通过ADH激活增强酒精代谢的一个有希望的领域.
- 需要进一步的研究来阐明具体的机制和优化应用.
- 这一综述为未来对ADH激活的研究提供了基础.
相关概念视频
Enzyme Inhibition
Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
Microbial Fermentation
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
Microbes in Food Production
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
Microbes in Beverage Production
Alcoholic beverages such as wine, beer, and spirits are the products of microbial fermentation processes that transform simple sugars into ethanol and a wide array of complex flavor compounds. These transformations rely on the metabolic activities of specific yeasts and bacteria, which are selected and controlled to yield the desired beverage characteristics.Wine Fermentation and MaturationWine production begins with the crushing of grapes to release juice and pulp, forming a must that is...
Production of Alcohol
Continuous fermentation is a key strategy in industrial ethanol production, particularly when efficiency, scalability, and high yields are essential. This approach allows for uninterrupted operation and optimized resource utilization. The primary feedstock, corn starch, undergoes enzymatic hydrolysis facilitated by α-amylase and glucoamylase. These enzymes break down the starch into fermentable sugars such as glucose, which are readily assimilated by fermentative microorganisms.Fermentation...
Production of Organic Acids
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...


