相关实验视频

Updated: May 27, 2025

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

在类风湿性关节炎中对T细胞的10年知识映射:一个文献计量分析

Yanfang Gao¹, Yang Liu^1,2, Huiqin Hao¹

¹Basic Laboratory of Integrated Traditional Chinese and Western Medicine, Shanxi University of Chinese Medicine, Jinzhong, China.

Human vaccines & immunotherapeutics

|February 18, 2025

概括

本文献分析揭示了2014-2023年T细胞和类风湿性关节炎 (RA) 的研究趋势. 关键领域包括免疫机制,肠道微生物群和RA治疗的生物疗法.

科学领域:

免疫学和风湿病学
生物医学研究趋势
图书统计分析图书统计分析

背景情况:

类风湿性关节炎 (RA) 是一种慢性自身免疫性关节疾病.
在RA的开始和进展中,T细胞至关重要.
对T细胞和RA的研究趋势缺乏全面的文献统计综合.

研究的目的:

描述T细胞和RA研究的演变和知识趋势.
确定该领域的关键研究热点和前沿.
为未来的科学研究和临床应用提供见解.

主要方法:

从2014年到2023年,对7037篇论文进行了图书统计分析.
来自Web of ScienceTM核心集合的数据.
使用CiteSpace和VOSviewer进行科学测量分析.

主要成果:

稳定的年度出版量 (600-800篇论文),引用频率不断增加.
贡献最多的国家:美国,中国,英国,日本.
领先的机构:卡罗林斯卡研究所,哈佛医学院.
著名的作者:Wei W,Cho ML,Park SH (多产);麦金尼斯IB,斯莫伦JS (高度引用).
主要期刊:免疫学的前沿,关节炎研究和治疗,关节炎和风湿病学.
研究热点:致病因素,向生物治疗,免疫/炎症机制,骨破坏.
新兴的前沿:肠道微生物群,纤维细胞样同胞细胞,介质干细胞,生物疗法和风险识别.

结论:

图书统计分析突出了RA中T细胞的动态研究格局.
确定了热点和边界,为治疗目标开发提供了方向.
这项研究为推进RA研究和临床实践提供了宝贵的见解.

关键词:

在CiteSpace中使用CiteSpace.一个T细胞细胞.这是Vosviewer的评论员.文献计量数据库 (bibliometrics) 是一个类风湿性关节炎类风湿性关节炎

更多相关视频

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...