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非肌肉侵入性膀癌与P-CRP及其名谱的预后评估

Junyun Wu¹, Zhixuan Deng², Xu Lei³

¹The Second Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Frontiers in oncology

|February 18, 2025

概括

手术前的血小板计数和C-反应蛋白 (P-CRP) 产品对非肌肉侵入性膀癌 (NMIBC) 无复发生存率 (RFS) 有影响. 结合P-CRP和病理数据的新Nomogram可以改善NMIBC患者的术后复发风险预测.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
生物标志物生物标志物

背景情况:

非肌肉侵入性膀癌 (NMIBC) 占膀癌诊断的大多数.
在NMIBC患者中预测无复发生存率 (RFS) 对于有效的术后管理至关重要.
当前的预测模型可能无法完全捕捉所有相关的预后因素.

研究的目的:

评估NMIBC中手术前血小板数和C反应蛋白 (P-CRP) 产物的预后价值.
开发和验证Nomogram用于预测NMIBC患者的RFS,这些患者接受了膀瘤通过尿道切除 (TURBT).

主要方法:

来自164名NMIBC患者的临床数据的回顾性分析,这些患者接受了TURBT.
卡普兰-梅尔分析和考克斯回归以确定RFS的独立预测因素.
使用一致性指数 (C指数) 和校准曲线构建和验证名图.

主要成果:

确定P-CRP产品是影响RFS的独立因素 (HR=0.357,P<0.001).
其他重要的预测因素包括瘤数量,瘤大小,T阶段和瘤G级.
开发的Nomogram表现出对1,2,3年RFS的良好预测准确性,超过了经典的EORTC风险模型.

结论:

手术前的P-CRP产品是TURBT后NMIBC患者RFS的显著预测因素.
一种将P-CRP与病理因素整合在一起的诺米图,可以在NMIBC中更好地预测术后复发风险.

关键词:

在P-CRP中,可以使用P-CRP.这个名字是名ogramogram.非肌肉侵袭性膀癌是非肌肉侵袭性膀癌.预后分析预后分析没有复发的生存率.

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