右半球在中风后认知障碍中的重要作用:一个功能近红外光谱学研究
Yinan Ai1, Yu Zhang1, Fang Zheng1
1The Third Affiliated Hospital, Sun Yat-sen University, Department of Rehabilitation Medicine, Guangzhou, China.
Neurophotonics
|February 18, 2025
概括
脑卒中后认知障碍 (PSCI) 显示整体大脑连接性降低,特别是在右半球. 神经调节策略应考虑右半球或双边半球的重点,以获得有效的治疗.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 目前用于中风后认知障碍 (PSCI) 的神经调节依赖于半球间抑制,主要用于运动缺陷.
- PSCI的潜在病理机制与运动障碍不同,并未完全理解.
- 了解PSCI的大脑特征对于开发有效的神经调节治疗至关重要.
研究的目的:
- 通过使用功能近红外光谱学 (fNIRS) 调查具有和没有失语症的PSCI中的功能连接 (FC) 模式.
- 建立一种病理基础,用于指导脑神经调节的策略中风患者的认知障碍.
主要方法:
- 收集了PSCI患者 (没有失语),中风后失语 (PSA),中风认知 (SC) 患者和健康对照 (HC) 的认知表现和fNIRS数据.
- 在PSCI,PSA,SC和HC组中分析了FC的差异.
- 与病变位置 (右半球与左半球) 和认知尺度相关联的FC发现.
主要成果:
- 与SC和HC组相比,PSCI患者的整体FC呈现较低.
- 与左半球患者相比,PSCI患者在右半球,右默认模式网络 (DMN) 和右中央执行网络 (CEN) 中的FC降低.
- 与对照组相比,PSA患者左半球FC增加,DMN/CEN FC没有显著差异.
- 在PSCI中右半球病变与较弱的FC和较差的认知表现相关.
结论:
- 在目前的神经调节方法中,右半球在PSCI中的作用可能被低估了.
- 未来的PSCI神经调节治疗应该考虑针对右半球或两半球.
- 这些发现为完善神经调节策略的病理基础,用于中风后认知恢复.
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