睡眠呼吸暂停,认知和阿司匹林对健康老年人的影响:ASPREE副研究
Stephanie A Ward1,2,3, Robyn L Woods1, Matthew T Naughton4
1School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
ERJ open research
|February 18, 2025
概括
在老年人中未被诊断的阻塞性睡眠呼吸暂停 (OSA) 与在三年内全球认知略有下降有关. 低剂量阿司匹林并没有阻止健康个体的认知衰退.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是痴呆症的潜在危险因素,但研究结果不一致.
- 研究未诊断的OSA与健康老年人的认知衰退之间的联系至关重要.
研究的目的:
- 确定未诊断的阻塞性睡眠呼吸暂停 (OSA) 是否与健康老年人的认知能力下降有关.
- 评估低剂量阿司匹林是否可以减轻OSA患者的认知衰退.
主要方法:
- 一项关于ASPirin in Reducing Events in the Elderly (ASPREE) 试验的副研究包括70岁以上没有痴呆症或心血管疾病的参与者.
- 家庭睡眠研究测量了氧气脱度指数以确定OSA. 参与者每天接受阿司匹林 (100毫克) 或安慰剂.
- 认知功能通过修改的迷你精神状态 (3MS) 检查和领域特定测试在三年内进行评估.
主要成果:
- 轻度OSA (49.0%) 和中度/重度OSA (31.5%) 与没有OSA (19.5%) 相比,在三年内与较低的3MS得分相关.
- 在OSA和特定领域认知测试下降之间没有发现显著的关联.
- 阿司匹林与OSA没有显著相互作用,以影响任何认知测试得分的变化.
结论:
- 阻塞性睡眠呼吸暂停与健康老年人的全球认知能力在三年内略有下降有关.
- 低剂量阿司匹林并没有减轻研究队列中的这种认知衰退.
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