中性粒细胞与高密度脂蛋白胆固醇比率与结石风险之间的关联:一个横截面研究
Yuan-Zhuo Du1, Jia-Qing Yang1, Ji-Ming Yao1
1Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Frontiers in endocrinology
|February 18, 2025
概括
较高的中性粒细胞与高密度脂蛋白胆固醇比率 (NHR) 与结石风险增加有关. 这一发现表明,NHR可能作为早期检测和个性化治疗策略的宝贵生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
- 公共卫生 公共卫生
背景情况:
- 结石对全球健康构成重大挑战,需要改进识别风险人群的方法.
- 早期检测和及时干预对于有效管理结石疾病至关重要.
研究的目的:
- 研究中性粒细胞与高密度脂蛋白胆固醇比率 (NHR) 与美国成年人结石患病率之间的关联.
- 为了确定NHR是否可以作为结石风险的预测生物标志物.
主要方法:
- 分析了2007-2018年国家健康和营养检查调查 (NHANES) 中24532名参与者的数据.
- 利用多变量逻辑回归模型来评估NHR和结石发生之间的关系.
- 采用受限立方线回归 (RCS) 来探索非线性关联,并进行子组分析.
主要成果:
- 共有2,351名参与者 (9.93%) 患有结石.
- 较高的NHR水平与结石风险增加显著相关 (OR=1.05,95%CI:1.02-1.08,P=0.002).
- 在NHR最高三位数的个体中,与最低三位数相比,患结石的可能性增加了34%.
结论:
- 较高的NHR独立地与较高的结石风险有关.
- 观察到的NHR与结石风险之间的关联在各种人口学子组中一致.
- 现在,NHR成为评估石风险的潜在临床生物标志物,有助于早期诊断和量身定制的治疗方法.
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