将免疫疗法与单独的化疗作为胆道恶性瘤的二线治疗方法进行比较:一项回顾性研究
Chengzhi Jiang1, Liu Yang1, Ling Yang Kong1
1Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
Clinical Medicine Insights. Oncology
|February 18, 2025
概括
免疫检查点抑制剂 (ICI) 与化疗相结合显示出显著的抗瘤活性和在晚期胆道癌 (BTC) 中可接受的安全性. ICI代表了一种有前途的二线治疗选择,用于高级BTC患者.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 胆管癌 (BTC) 是一种罕见的胃肠道恶性瘤,在一线治疗后的管理选择有限.
- 免疫检查点抑制剂 (ICI) 越来越多地用于固体瘤,它们与化疗的结合是各种癌症的标准.
- 在先进的BTC中ICI的有效性和安全性需要进一步研究.
研究的目的:
- 评估免疫治疗的疗效和安全性,特别是免疫检查点抑制剂 (ICI),作为晚期胆道癌 (BTC) 的二线治疗.
- 为了比较单独接受化疗 (SC) 和接受化疗与ICI (CT) 结合治疗的患者之间的结果.
主要方法:
- 一项回顾性研究包括在2014年至2024年期间在一线治疗失败后接受BTC治疗的126名患者.
- 患者被分为简单化疗 (SC) (n=69) 或化疗加ICI (CT) (n=57) 组.
- 主要终点是总生存 (OS);次要终点包括无进展生存 (PFS),客观反应率 (ORR),疾病控制率 (DCR) 和与治疗相关的不良反应 (TRAEs).
主要成果:
- 与SC组相比,CT组在PFS (4.68个月) 和OS (30.26个月) 中呈现出统计学上显著的改善 (P < .001).
- 对象反应率 (ORR) 在CT组为5.26%,在SC组为1.45%,疾病控制率 (DCR) 分别为54.39%和33.33%.
- 组织学差异化和CA199水平的降低被确定为OS的独立预后因素. 3-4级不良事件主要是血红蛋白降低 (29.37%).
结论:
- 结合免疫疗法与化疗显示出显著的抗瘤活性和可接受的安全性在先进的BTC.
- 免疫检查点抑制剂显示出作为高级BTC可靠的二线治疗的潜力,改善生存结果.
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