由肠道含量微生物群介导的肠-大脑轴与石陶志煮与便秘有关
Leyao Fang1,2,3, Xin Yi2,3, Junxi Shen2,3
1The First Hospital of Hunan University of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
石 (Zhishi Daozhi decoction,简称ZDD) 通过恢复肠道微生物群平衡和影响肠-大脑轴信号传递,有效治疗便秘. 中剂量ZDD在改善肠道健康方面显示出最有前途的结果.
科学领域:
- 胃肠病学和中国传统医学
- 微生物组研究 微生物组研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 便秘是一种普遍的消化系统疾病,与肠道微生物群的改变有关.
- 济西大子 (Zhiishi Daozhi decoction,简称ZDD) 是一种传统中医药配方,用于治疗与消化不良相关的便秘.
研究的目的:
- 评估Zhiishi Daozhi (ZDD) 在治疗便秘方面的治疗效果.
- 研究ZDD对便秘的影响的潜在机制,重点关注肠道微生物群和相关信号通路.
主要方法:
- 在昆明小鼠中使用高蛋白,高脂肪饮食和洛佩拉米德化物实验诱导便秘.
- 小鼠接受了ZDD (2.4,4.7和9.4毫克/公斤) 的不同剂量,持续7天.
- 分析了便中的微生物活动,肠道微生物组合 (通过16SrRNA测序),以及5-hydroxytryptamine (5-HT),血管活性肠道 (VIP) 和水素-3 (AQP3) 的水平.
主要成果:
- 与便秘模型组相比,ZDD治疗改善了便质地和正常化便微生物活动.
- 中高剂量的ZDD显著恢复了肠道微生物群结构,减少了致病细菌,增加了有益细菌.
- 相关性分析表明了特定肠道细菌与神经递质/水平 (5-HT,VIP) 之间的关系.
结论:
- 高蛋白,高脂肪饮食和洛佩拉胺引起的便秘显著改变了肠道微生物群的结构.
- 通过调节肠道微生物群和影响大脑-肠轴,ZDD显示出缓解便秘的潜力.
- 发现中剂量的ZDD在改善便秘症状和恢复肠道平衡方面是最有效的.
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