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酸解锁双层Ca装载纳米平台干扰线粒体,用于协同瘤治疗

Yilu Zheng¹, Gareth R Williams², Ran Hu¹

¹College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People's Republic of China.

International journal of nanomedicine

|February 18, 2025

概括

这项研究引入了一种新型纳米炸弹,可以在瘤中选择性释放和过氧化,触发细胞死亡. 这种方法显示了通过诱导免疫细胞死亡来有效的,能源独立的抗瘤治疗的希望.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

针对瘤细胞向和破坏而没有外部能量的选择性配方对于先进的抗瘤疗法至关重要.
目前的战略旨在开发具有增强瘤杀伤能力的新型治疗剂.

研究的目的:

开发和描述一种用于选择性瘤细胞破坏的"纳米炸弹" (CaO2@ZIF8:CUR@PAA).
研究瘤微环境中风和氧化损伤的作用机制.
为了评估这个纳米平台在抑制瘤生长和转移方面的治疗效果.

主要方法:

一个新的纳米炸弹,CaO2@ZIF8:CUR@PAA,用双层外合成,用于酸触发的释放.
纳米炸弹在酸性瘤微环境中释放离子 (Ca2+) 和过氧化 (H2O2).
黄素 (CUR) 被纳入,以增强细胞内积累和氧化应激.

主要成果:

纳米炸弹展示了酸触发的降解,释放Ca2+和H2O2,导致"风暴"和氧化损伤.
这些影响诱导了线粒体功能障碍,细胞循环停止和瘤细胞的亡.
治疗触发了免疫细胞死亡 (ICD),促进了M1巨细胞的两极分化,并抑制了瘤的扩散和转移.

结论:

开发的酸两步解锁纳米平台有效地结合了风暴和氧化损伤,用于癌症治疗.
这种方法诱导了亡和ICD,导致细胞循环阻塞和瘤生长的抑制.
这种CaO2@ZIF8:CUR@PAA纳米炸弹显示出作为一种免疫触发癌症治疗的抗癌平台的巨大潜力.

关键词:

离子负载的加离子负载.这是一种抗癌药物.有控制释放的纳米材料.药物释放是响应pH的药物释放.有活性氧物种的反应性氧物种.两层保护的保护外有两个层.

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