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脑血管疾病和晚年抑郁症:一个范围审查

Harris A Kalim¹, Tahreem Hussain¹, Maria Colon¹

¹Medical School, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA.

|February 18, 2025

概括

大脑小血管疾病 (CSVD) 与老年人的晚年抑郁症 (LLD) 有关. 这次审查发现,大多数研究都显示出显著的相关性,白质超强度是常见的因素.

科学领域:

神经学神经学
老年病的医生老年病的医生
精神病学是一个精神病学.

背景情况:

大脑小血管疾病 (CSVD) 包含影响大脑血管系统的渐进性疾病,常见于老年患者.
晚年抑郁症 (LLD) 在老年人中很普遍,但其与CSVD的关联尚未完全理解.
脑血管疾病与高血压有关,导致微血管损伤和大脑输液减少.

研究的目的:

综合有关老年人中CSVD和LLD病理生理学和联系因素的证据.
评估现有的关于50岁及以上个体中CSVD和抑郁症之间的关系的文献.

主要方法:

在EMBASE,Ovid MEDLINE和Web of Science中进行了系统的文献搜索.
包括1998年至2022年出版的英语同行评审文章,重点关注50岁以上患有抑郁症和CSVD的个人.
20项研究符合标准,经过分析,包括统计相关性.

主要成果:

20项研究中有15项报告说,CSVD和LLD之间存在统计学上显著的相关性.
总共有15,158名参与者被纳入研究中,这些研究表明了显著的联系,平均每项研究为1,011.
白质过强度 (WMHs),一个CSVD标志物,在LLD患者中很常见,WMH体积增加与抑郁症状相关.

结论:

审查的调查结果支持CSVD和LLD之间存在重要的关系.
诸如神经炎症和系统性并发症等非血管因素也会影响这种复杂的关联.
早期CSVD检测和跨学科方法对于管理老年人群中抑郁症和认知衰退至关重要.

关键词:

脑血管疾病脑血管疾病认知障碍是一种认知障碍.晚年生活中的抑郁症.微血管抑郁症是什么意思血管标志物血管标志物白质病变 - 白质病变的病变

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