八种全血细胞计衍生炎症标志物与肌肉健康之间的关联
Jingyuan Zhang1, Yuqi Wang2, Heng Liu3
1Department of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Frontiers in nutrition
|February 18, 2025
概括
系统性免疫炎症指数 (SII) 有效地识别低肌肉质量和力量,优于其他炎症标志物. 这一指数对于检测"隐藏的缩症"和早期肌肉衰退至关重要.
科学领域:
- 老年学是指老年学的学科.
- 炎症研究 炎症研究
- 肌肉生理学 肌肉生理学
背景情况:
- 肉症和肌肉健康通常仅由肌肉质量来评估.
- 综合评估肌肉健康需要考虑多个维度,包括炎症指标.
研究的目的:
- 研究八种炎症指标与肌肉质量和力量之间的关联.
- 为多维肌肉健康评估确定可靠的炎症指标.
主要方法:
- 使用了来自10,440名参与者的数据 (NHANES 2011-2018) 和5,384名参与者的数据 (NHANES 2011-2014).
- 采用多变量逻辑回归,平滑曲线拟合,受限立方线 (RCS) 分析,子组分析和斯皮尔曼相关性.
- 与554名医院患者进行了交叉验证,以评估系统性免疫炎症指数 (SII) 的预测能力.
主要成果:
- 系统性免疫炎症指数 (SII),中性粒细胞与淋巴细胞比率 (NLR) 和中性粒细胞与单细胞加上淋巴细胞比率 (NMLR) 显示出与肌肉质量和力量的显著负相关性,独立于BMI.
- 在低肌肉质量 (AUC ≈0.69) 和低肌肉强度 (AUC ≈0.85) 方面,SII表现出强大的预测性能.
- 大多数炎症标志物与肌肉健康指标呈现线性相关性.
结论:
- SII是评估肌肉健康的有价值和强大的指标,其表现优于其他炎症标志物.
- SII对于识别"隐藏的"和肌肉功能衰退的早期阶段至关重要.
- SII表现出高的概括性表现,并且对共变量的影响较小.
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