肌菌菌种感染的临床特征和结果
Mayyadah H Alabdely1, Kristin Englund1, Nabin K Shrestha1
1Infectious Disease Department, Cleveland Clinic, Cleveland, Ohio, USA.
Open forum infectious diseases
|February 18, 2025
概括
在住院患者中研究了经常被认为具有耐药性的肌痛性腺体感染. 这项研究发现感染患者和对照人群之间没有显著的生存差异,这表明 Myroides 感染是可以治疗的.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- Myroides物种,是Flavobacteriaceae家族中的グラム阴性细菌,通常具有低毒性,但以广泛的耐药性而闻名.
- 这项研究侧重于疹感染的临床特征和结果.
研究的目的:
- 为了研究状腺感染的临床特征和结果.
- 为了评估Myroides分离物的抗生素敏感性模式.
- 为了比较患有甲状腺感染的患者和未感染的对照人群之间的生存率.
主要方法:
- 在克利夫兰诊所进行了一项回顾性队列研究.
- 感染被定义为来自无菌部位的阳性Myroides培养物,经过敏感抗生素治疗.
- 感染患者和未感染的对照人群之间使用Cox回归来比较生存率.
主要成果:
- 在2015年1月至2023年9月期间,在52种阳性培养物中发现了21种肌炎感染.
- 皮肤/软组织感染,骨髓炎和尿路感染是最常见的;28.5%患有细菌血症.
- 所有分离物都对氨基糖化物有耐药性,但对三甲-硫甲醇 (81%),美罗 (68%) 和西普洛素 (57%) 有敏感性.
- 在感染患者和对照人群之间没有观察到显著的生存差异 (HR, 3.42; P = .16).
结论:
- 与之前的报道相反,这个队列中的肌炎感染有可行的治疗选择.
- 该研究没有发现与对照组相比,疹感染患者的存活率在统计学上有显著的影响.
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