2岁以下的营养不良儿童的营养管理和结果,肠道衰竭
Estela Cristina Pavanelli1,2,3, Joao Seda Neto1,2,3, Beatriz Camilo Farah1,2,3
1Intestinal Rehabilitation and Transplant Center, Hospital Sirio-Libanes, Sao Paulo, Sao Paulo, Brazil.
Journal of pediatric gastroenterology and nutrition
|February 18, 2025
概括
患有肠道衰竭的两岁以下儿童的严重营养不良可以通过多学科护理逆转. PN依赖指数 (PNDI) 可以预测肠道自主性 (EA).
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
- 临床营养学 临床营养学
背景情况:
- 两岁以下儿童的肠衰竭 (IF) 通常导致营养不良.
- 亲肠道营养 (PN) 对于管理IF至关重要,但存在风险.
- 评估营养状况和PN依赖性对于患者的治疗结果至关重要.
研究的目的:
- 为了评估儿科IF患者的营养状况变化.
- 分析腹腔营养 (PN) 组成及其演变.
- 确定PN依赖指数 (PNDI) 对肠内自主 (EA) 的预测值.
主要方法:
- 对24个月以下的IF患者进行了回顾性队列研究,这些患者营养不良.
- 12个月的随访,包括人体测量和生化数据.
- 全自主 (EA) 和非EA组之间的PNDI比较.
主要成果:
- 短肠综合征 (SBS) 是IF的主要原因 (90%).
- 呈现严重营养不良的患者 (Wt/A和Ht/Az分数<-3).
- 5个月的Wt/A z-score显著改善;EA组从6个月开始显示较低的PNDI (p=0.032).
结论:
- 多学科护理有效地扭转了儿科FI的严重营养不良.
- PNDI显示了作为实现全身自主 (EA) 的预测因素的潜力.
- 在EA和非EA组中都实现了营养恢复.
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