肥胖个体中每日尿路肌素分泌的标准参考:一个单心,回顾性,观察性研究
Raphaël Cohen1, Caroline Prot-Bertoye2, Claire Rives-Lange3
1Service de Physiologie, Exploration Fonctionelles Rénales et Métaboliques, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France; Centre de Référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte (MARHEA), Paris, France; Centre de Référence des Maladies Rares du Calcium et du Phosphate, Paris, France.
在肥胖的人群中,每日尿路肌素分泌量较高. 这项研究提出了在肥胖人口中尿路肌素分泌的新参考值,这对于准确的24小时尿液采集解释至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 临床化学 临床化学
- 肥胖医学 肥胖医学
背景情况:
- 24小时尿道收集对于管理诸如结石,肥胖,高血压和慢性病 (CKD) 等疾病至关重要.
- 尿路肌素分泌评估了收集的完整性,反映了肌肉质量.
- 尿肌的当前参考值可能不适用于由于身体组成不同而患有肥胖的人.
研究的目的:
- 为了确定每日尿路肌素分泌的参考值,特别是在肥胖人口中.
- 调查现有的参考值是否适用于肥胖患者.
主要方法:
- 一项回顾性观察性研究包括了接受球过率 (GFR) 测量的成年患者.
- 额外推算的24小时尿路肌素分泌量 (exUCreat24) 由定时尿液收集计算出来.
- exUCreat24在肥胖个体和健康体重对照组之间进行了比较,对关键的人口统计和临床因素进行了匹配.
主要成果:
- 该研究包括1091名患者,其中227人被确定为肥胖.
- 肥胖个体表现出明显更高的exUCreat24 (13.9 mmol/24h) 与健康体重个体 (11.0 mmol/24h) 相比.
- 在肥胖个体中,体重调整后的exUCreat24百分位与一般人口数据有显著差异.
结论:
- 在肥胖的人群中,每日尿路肌素分泌量显然更高.
- 建议在肥胖人群中对尿路肌素分泌的新标准参考值.
- 对肥胖患者24小时尿液采集的准确解释需要特定人群的肌素分泌标准.
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