探索粘膜口膜在老年医学中的潜力
Jasmine Southward1, Fang Liu1, Sam R Aspinall1
1Department of Clinical, pharmaceutical and biological sciences, School of Life and Medical Sciences, University of Hertfordshire, College Lane, Hatfield, UK.
Drug development and industrial pharmacy
|February 18, 2025
概括
粘膜口膜 (MBF) 为患有吞困难的老年患者提供了一个有前途的解决方案,简化了药物输送. 本综述探讨了与年龄相关的口腔变化和优化老年人群MBF疗效的策略.
科学领域:
- 老年医学 老年医学
- 药品制造 药品制造 药品制造
- 生物材料科学 生物材料科学
背景情况:
- 全球人口正在老龄化,导致患有复杂口服药物治疗方案的并发病的老年患者数量增加.
- 老年患者的缺食症对传统的口服药物给药提出了重大挑战,可能导致治疗坚持和疗效降低.
- 粘膜口膜 (MBF) 正成为一种可行的替代方案,提供简化管理,减少药片负担,并有可能进行个性化剂量.
研究的目的:
- 审查影响药物输送的口腔年龄相关变化.
- 探索粘膜口膜 (MBF) 对老年患者的潜力.
- 确定克服与年龄相关的MBF疗效障碍的策略.
主要方法:
- 文献综述,重点关注衰老对口腔粘膜和唾液的影响.
- 对粘粘膜口膜应用的研究分析.
- 研究透增强剂和3D打印用于口膜优化.
主要成果:
- 衰老显著改变口腔粘膜的特性和唾液成分,影响药物吸收.
- 已经研究了各种透增强剂,以改善通过老年人口腔粘膜的药物透.
- 3D打印技术在制造具有量身定制剂量的粘膜口膜方面提供了更大的灵活性.
结论:
- 粘膜口膜为老年患者提供了一个有前途的药物输送系统,解决了与衰老和消化不良相关的挑战.
- 了解和减轻口腔环境中与年龄相关的变化对于成功开发和应用MBF至关重要.
- 像3D打印这样的创新可以通过为老年人提供定制和灵活的药物输送解决方案,进一步提高MBF的实用性.
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